Verruciform xanthoma of the palatal gingiva: a report of two cases
류다정, 이상훈, Yuk Jong-In, 김형준, 허종기, 박광호,
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류다정 ( Ryu Da-Jung ) - Yonsei University College of Dentistry Gangnam Severance Dental Hospital Department of Oral and Maxillofacial Surgery
이상훈 ( Lee Sang-Hoon ) - Yonsei University College of Dentistry Gangnam Severance Dental Hospital Department of Oral and Maxillofacial Surgery
( Yuk Jong-In ) - Yonsei University College of Dentistry Department of Oral Pathology
김형준 ( Kim Hyung-Jun ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
허종기 ( Huh Jong-Ki ) - Yonsei University College of Dentistry Gangnam Severance Dental Hospital Department of Oral and Maxillofacial Surgery
박광호 ( Park Kwang-Ho ) - Yonsei University College of Dentistry Gangnam Severance Dental Hospital Department of Oral and Maxillofacial Surgery
KMID : 0355620130390060292
Abstract
Verruciform xanthoma (VX) is a rare, benign lesion that presents in the oral cavity, skin, or genital organs as a verrucous, papillomatous, or flat papule with varying colors. VX has indistinct clinical features, making histopathological examination necessary for a definitive diagnosis. Histologically, VX is characterized by parakeratosis, rete ridges with uniform depth, and an accumulation of the foam cells, which are also known as the “xanthoma cells”. These foam cells test positive for antibodies, such as CD-68 and vimentin; it is thought that VX foam cells are derived from the monocyte-macrophage lineage, and that VX’s pathogenic mechanism is partly related to an immune mechanism. Nevertheless, the pathogenesis of VX remains unclear. VX can be treated by surgical excision; other medical, chemical, and radiological treatments are not required postoperatively. Recurrence and malignant transformation of VX are rare. Two patients, each with a mass of unknown origin on the palatal gingiva, were presented at our clinic. Excisional biopsies of the masses were performed for a histological diagnosis after clinical and radiological examinations. Histological examination confirmed a diagnosis of VX in both cases.
키워드
Verruciform xanthoma; Mouth; Foam cells; Immune mechanism
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